Rusted Lab's blog posts tagged with 'research'

Next generation of dementia scientists to explore genetic risk of Alzheimer’s



A gene that increases the risk of Alzheimer’s disease by up to 10 times will be the focus of a new research centre at the University of Sussex launched today (Thursday 5 February).

Funded by Alzheimer’s Society and matched funding, the new Doctoral Training Centre will support eight PhD students over five years to research the effects of the APOE4 gene.

Carriers of this gene have increased risk of developing Alzheimer’s disease, although not all people with the gene develop the condition, and not all people with Alzheimer’s have the gene.

The students funded through the centre will explore how this gene affects the brain at all ages, in particular how it affects key parts of the brain associated with memory and learning, why the proteins made by this gene are different and how they potentially can be altered.

The centre is being led by biochemist Professor Louise Serpell, who is investigating toxic particles that cause degeneration in brain cells, and psychologist Professor Jennifer Rusted, whose research  looks at the gene-environment interplay in cognitive ageing.

Professor Rusted said: “The Alzheimer’s Society Doctoral Training Centre at the University of Sussex will provide a great opportunity to enhance the research into the causes of and treatments for this devastating disease that is already being carried out in the Schools of Psychology and Life Sciences.”

Professor Serpell said: “We are honoured to accept this award from Alzheimer’s Society and to be able to play a major part in the international focus to understand and tackle the challenges of this disease.”

The Doctoral Training Centre is funded by a £350,000 grant from Alzheimer’s Society and matched funding leveraged as a result of the Society’s investment, from the Sussex Doctoral School and the Schools of Life Sciences and Psychology at the University.

Sussex philanthropist and businessman Michael Chowen CBE, who has made a substantial gift to the centre, said: “Having supported both Professor Serpell’s and Professor Rusted's pioneering research on Alzheimer's disease for some time, I am delighted that I have been able to contribute towards the new Doctoral Training Centre.

"I wish them, and the colleagues and students who will be engaged in this Doctoral Centre with them, every success in their efforts to combat this cruel disease.”

Professor Michael Davies, Pro-Vice-Chancellor (Research), said: “We are delighted to be working with Alzheimer’s Society on dementia research and for the Society’s recognition of the quality of our doctoral provision in the Schools of Life Sciences and Psychology.”

The Sussex centre is one of eight new specialist centres around the country that are being co-ordinated and funded by Alzheimer’s Society. With additional funding from institutions, this represents nearly £5 million in new investment to support 55 PhDs and clinical fellows – the single biggest funding commitment to support early-career dementia researchers in the UK.

Dr Doug Brown, Director of Research at Alzheimer’s Society, said: “There’s a huge amount of progress being made by the dementia research community but unless we attract and train the best young talent we will limit how quickly we can make ground-breaking discoveries. For too long dementia research has been underfunded and as a result we have significantly fewer scientists than other conditions.”

Encouraging Children to Act Out!



In addition to aging and dementia, the Rusted Lab is curious about the development of children and how it compares to the aging process later on in life. Molly Berenhaus, a second year PhD student and devoted member of the Rusted lab, is currently looking at the benefits of action (e.g., hand movements) and externalisation (e.g., creating a storyboard) on children’s understanding  and appreciation of short stories.  

Over the course of this academic year, Molly has been working with children in year 5 at a local primary school to investigate the benefits of two strategies on reading comprehension processes. Specifically she’s comparing the benefits of encouraging children to construct a visual representation of a short story (“Storyboard Construction”) using plastic cut-outs to the benefits of encouraging children to act out a short story (“Active Experiencing”) using different voices and hand movements. Both strategies have been found to help children understand what they’re reading (and enjoy doing it!) but now we have to find out  what specific aspects of a story they help children understand (The layout of the scene? Information about the protagonist?). Molly’s research is interested in just that! 

To find out more, please contact Molly at

Jenny Rusted's Lab Group website.

HCV Treatment in HIV HCV co infection population



Research in the Rusted Lab includes a study of the potential adverse side effects of hepatitis C treatment in HIV-positive individuals with a concurrent Hepatitis C infection – this is a condition that affects 40% of HIV patients. In these patients, the treatment of the Hepatitis C infection has been associated with depressive symptoms and cognitive impairments both of which negatively impact the quality of life of the patients.

The current standard of care for hepatitis C involves a combination of drugs (interferon and ribavirin) however; the treatment options have changed with the development of new therapies using interferon, ribavirin plus a new drug that have improved HCV cure rates. It is well known that depression is the most prevalent side effect of interferon and ribavirin treatment but little is known about the adverse events in the new treatment.

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Renata Fialho a second year PhD student and member of the Rusted Lab is looking at the adverse effects during hepatitis C treatment with classic and new treatment in HIV/HCV patients. According with preliminary results fifty participants were included in the study. We looked at differences on depression between hepatitis C treatments and there was a significant increase in depression in both types of treatments. These results suggest that the prevalence of depression is high still and more research is needed in order to clarify what type of depression and cognitive symptoms are associated with hepatitis C treatment.

For more information on the research being ran by the lab group, see our website

For the official lab blog, click here 

International collaboration- members of the Rusted Lab group make friends with Sao Paulo



International collaboration- members of the Rusted Lab group make friends with Sao Paulo

Two members of the Rusted lab group, Simon Evans and Claire Lancaster, visited Brazil for a week this April. Sounds like a holiday, but this trip was part of a specially formed scheme to encourage international research collaborations, funded by Santander Mobility Grants scheme.

The trip centred around a visit to Sao Paulo, hosted by Sabine Pompeia, an associate Professor of Psychobiology at the Federal University of Sao Paulo. We were welcomed by her lab group on the Monday and the first thing that struck us was their enthusiasm for research. Many excellent talks were delivered during our visit, but the work of three researchers stood out in terms of the exciting opportunities present for future international collaboration.


Fifteen years previously, Sabine had spent time working in the Rusted lab in Sussex. Her current research is concerned with developing tasks that explore executive functioning – our capacity to multi-task. Although much of her research has applied this battery to specific populations, she has also been involved in large Brazilian epidemiological studies. As part of future joint work between the Rusted and Pompeia groups, we hope to explore the role of the APOE gene, a genetic risk factor for dementia, on executive function at different stages of development.

We were also introduced to Andre Negrao, a clinical academic from the Genetic and Molecular Cardiology lab. Andre is currently researching the genetic, biological and cognitive profile of the population of Baependi, a town of 18,000 in south-east Brazil. This town is of interest due to the mix of urban and rural people living there, and the diverse range of educational and SES backgrounds. In the future, we hope to work with Andre and his team combining our joint interests in genetic differences in brain structure and function , and cognition.

Future collaborations with Monica Yassuda are also in the pipeline. Monica is a practicing neuropsychiatrist and academic at the University of Sao Paulo, typically working with more elderly populations, especially those with MCI.

One of the most important things we took away from our time in Sao Paulo was the problem administering tasks cross-culturally. Measures well-established in one country may not necessarily be suitable for administration in others. For example, using the word ‘snow’ as a stimuli in a language-based task is not so simple as it sounds. In some countries snow is a very common word, in others it is rarely used. Brazil is a country with a diverse profile of socio-economic and educational backgrounds, and as such cognitive tests need to be designed to suit varying rates of literacy. A major focus within the lab group we visited was modifying cognitive tasks for use in Brazil, thinking of clever adaptations to make them free of reading and writing requirements and accessible for all. These are important considerations for us to bear in mind when designing future collaborations.

But the trip was a wonderful insight into the culture of another country and we would like to thank our wonderful host Sabine for taking us round the city, and her team for welcoming us to the University. We would also like to thank Santander for the opportunity their funds provided, and Dr Paul Roberts at the Doctoral School for supporting the application.

Sabine Pompeia’s homepage 

Rusted Lab website